Automated DNA fragments recognition and sizing through AFM image processing.

This paper presents an automated algorithm to determine DNA fragment size from atomic force microscope images and to extract the molecular profiles. The sizing of DNA fragments is a widely used procedure for investigating the physical properties of individual or protein-bound DNA molecules. Several...

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Detalhes bibliográficos
Publicado no:	IEEE Transactions on information technology in biomedicine 9, 4 (2005).
Autor principal:	Ficarra, E.
Formato:	Artigo
Idioma:	English
Assuntos:	AFM image processing. DNA fragment size. DNA secondary structure transition. Atomic force microscope images. Automated DNA fragments recognition. Automated algorithm. Background noise. Computer-generated images. Image pixel size. Length estimation. Manual DNA sizing. Molecular profile. Molecular profile extraction. Physical properties. Processing time. Protein-bound DNA molecule. Root mean square error. Semiautomated DNA sizing. Structural analysis.