Addressing cell-sourcing limitations with gene therapy.

Genetic engineering with Run×2/Cbfa 1 for an alternative to biological grafts. Forced Runx2 expression via retroviral gene delivery promotes osteoblastic differentiation and mineralization in bone marrow stromal cells and stimulates conversion of myoblasts and dermal fibroblasts into a mineralizing...

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Bibliographic Details

Published in:	IEEE Engineering in medicine and biology magazine 22, 5 (2003).
Main Author:	Garcia, A.J
Format:	Article
Language:	English
Subjects:	Bone marrow stromal cells. Bone tissue engineering. Cell-sourcing limitations. Dermal fibroblasts. Genetic engineering strategy. Mineralization. Mineralizing osteoblastic phenotype. Osteoblastic differentiation. Retroviral gene delivery.