RNA antagonists - a new class of antisense drugs.

The locked nucleic acid (LNA) chemistry brings truly stunning affinity and high biostability to the world of nucleic acids. In turn, these features enable the design of shorter-than-usual oligos that exhibit unprecedented potency, good specificity, high biostability, good biodistribution, and low to...

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Bibliographic Details

Published in:	IEEE Engineering in medicine and biology magazine 24, 4 (2005).
Main Author:	Orum, H.
Format:	Article
Language:	English
Subjects:	RNA antagonists. Affinity. Antisense drugs. Antisense therapy. Biodistribution. Biostability. Direct bolus injection. Dosing regimens. Good specificity. Locked nucleic acid. Low toxicity. Oligos. Phosphorothioate chemistry. Potency.