Control of cell metabolism and multiplicity of steady state in the continuous culture of hybridoma cells
Under typical culture conditions, mammalian cells convert as much as 95% of the glucose consumed into lactic acid. The accumulation of lactate has adverse effects on cell growth and could limit the maximum cell concentration that can be achieved in the culture. Using a fed-batch culture to cultivate...
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| Formato: | Electronic Resource |
| Idioma: | English |
| Publicado em: |
Ann Arbor Michigan
Bell & Howell Information and Learning Company
[2001]
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