00000cmm a2200000 i 4500 UP-99796217613500803 Buklod 20220905123954.0 m o u cr || |||a|a|a 220905s2017 enk u eng c 9780128027349 0128027347 (iLib)UPD-00517672177 DLC DSCI rda eng DMLUC QH 588 S83 B56 2017eb Biology and engineering of stem cell niches edited by Ajaykumar Vishwakarma, Jeffrey M. Karp. London Elsevier/Academic Press [2017] 1 online resource (xv, 625 pages) illustrations (chiefly color) text rdacontent computer rdamedia online resource rdacarrier Includes bibliographical references and index. I. Biology of stem cell niches and molecular mechanisms -- The need to study, mimic, and target stem cell niches -- Harnessing the biology of stem cells' niche -- Pluripotent stem cell microenvironment -- Regulation of hematopoietic stem cell dynamics by molecular niche signaling -- HSC niche: regulation of mobilization and homing -- Neuronal stem cells niches of the brain -- Cardiovascular stem cell niche -- Intestinal epithelial Lgr5+ stem cell niche and organoids -- The epithelial stem cell niche in skin -- The satellite cell niche in skeletal muscle -- The cancer stem cell niche -- Cellular senescence and stem cell niche -- Biochemical and physical cues in the stem cell niche directing cell fate -- Matrix chemistry controlling stem cell behavior -- Matrix growth factor and surface ligand presentation -- Effects of matrix mechanical forces and geometry on stem cell behavior -- Wettability effect on stem cell behavior -- Fluid flow control of stem cells with investigation of mechanotransduction pathways -- Hypoxia regulation of stem cell: mechanisms, biological properties, and applications -- III. Designing smart biomaterials to mimic and control stem cell niche -- Polymer design and development -- Design and development of ceramics and glasses -- Surface functionalization of biomaterials -- Biofunctional hydrogels for three-dimensional stem cell culture -- Technologies to engineer cell substrate mechanics in hydrogels -- Micro- and nanosurface patterning technologies -- Self-assembled nanostructures (SANs) -- Biometric nanofibers as artificial stem cell niche -- IV. Bioengineering strategies to model synthetic stem cell niches -- Employing microfluidic devices to induce concentration gradients -- Engineering niches for embryonic and induced pluripotent stem cells -- Engineering niches for cardiovascular tissue regeneration -- Engineering niches for blood vessel regeneration -- Engineering niches for bone tissue regeneration -- Engineering vascular niche for bone tissue regeneration -- Engineering niches for cartilage tissue regeneration -- Engineering niches for stem and progenitor cell differentiation into immune cells -- Engineering niches for skin and wound healing -- Designing stem cell niche for liver development and regeneration -- Engineering the niche for intestinal regeneration. IP-based subscription, on campus only. Access via Electronic Resources of the UPD University Library Website. Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type.--Provided by publisher. Stem cells. Stem Cell Niche physiology. Cell Engineering. Biocompatible Materials. Electronic books. Vishwakarma, Ajaykumar editor. Karp, Jeffrey editor. Electronic Resource https://www.sciencedirect.com/book/9780128027349/biology-and-engineering-of-stem-cell-niches Available for University of the Philippines System via SpringerLink. Click here to access FO UPD DSCI Electronic Resource