00000cam a22000004i 4500 UP-99796217612386573 Buklod 20170217155440.0 a r |||| u| ta 111130s2012 nyua rb |001 0|eng d 9781617795190 (iLib)UPD-00261910632 DLC DIC rda eng RS 420 S77 2012 Structure-based drug discovery edited by Leslie W. Tari. New York Humana Press/Springer [2012] ix, 385 pages illustrations (some color) 27 cm text rdacontent unmediated rdamedia volume rdacarrier Methods in molecular biology 841 Includes bibliographical references and index. The utility of structural biology in drug discovery / Leslie W. Tari -- Genetic construct design and recombinant protein expression for structural biology / Suzanne C. Edavettal, Michael J. Hunter, and Ronald V. Swanson -- Purification of proteins for crystallographic applications / Daniel C. Bensen -- Protein crystallization for structure-based drug design / Isaac D. Hoffman -- X-ray sources and high-throughput data collection methods / Gyorgy Snell -- The use of molecular graphics in structure-based drug design / Paul Emsley and Judit É. Debreczeni -- Crystallographic fragment screening / John Badger -- The role of enzymology in a structure-based drug discovery program : bacterial DNA gyrase / Mark L. Cunningham -- Leveraging structural information for the discovery of new drugs : computational methods / Toan B. Nguyen, Sergio E. Wong, and Felice C. Lightstone -- Chemical informatics : using molecular shape descriptors in structure-based drug design / Andy Jennings -- Accounting for solvent in structure-based drug design / Leslie W. Tari -- Structure-based drug design on membrane protein targets : human integral membrane protein 5-lipoxygenase-activating protein / Andrew D. Ferguson -- Application of SBDD to the discovery of new antibacterial drugs / John Finn -- Leveraging SBDD in protein therapeutic development : antibody engineering / Gary L. Gilliland ... [et al.] -- A medicinal chemistry perspective on structure-based drug design and development / Shawn P. Maddaford. Drugs Design Laboratory manuals. Drug Discovery Methods Laboratory manuals. Molecular conformation Laboratory manuals. Computational Biology Methods Laboratory manuals. Tari, Leslie W. editor. Methods in molecular biology 841. FO UPD DIC RS 420 S77 2012 Book