Male-mediated developmental toxicity - Anderson, Diana; Brinkworth, Martin H. (Cambridge, UK RSC Publishing, 2007)
Epigenetic transgenerational actions of endocrine disruptors through the male germ-line -- Reproductive outcomes among men treated for cancer -- Paediatric cancer : an indicator of familial cancer risk? -- What harms the developing male reproductive system? -- Links between paternal smoking and childhood cancer -- Feasibility study of metal effects on the X:Y ratio in human sperm -- Use of the sperm chromatin structure assay (SCSA) as a diagnostic tool in the human infertility clinic -- Safety of sperm for use in intra-cytoplasmic sperm injection -- Male-mediated F1 effects in mice exposed to di(2-ethylhexyl)phthalate (DEHP) -- Prevention of adverse effects of cancer treatment on the germline -- Molecular changes in sperm and early embryos after paternal exposure to a chemotherapeutic agent -- Transmissible genetic risk causing tumours in mice and humans -- Heritable effects on DNA damage following paternal F0 germline irradiation -- Influence of DNA methylation and genomic imprinting in the male germ line on pregnancy outcome -- Information content of ejaculate spermatozoa and its potential utility in toxicology and infertility based research programmes -- Origin of paternal mutations -- Redox regulation of dna damage in the male germ line -- Advances in the direct measurements of partial chromosomal duplication, deletions and breaks in human and murine sperm by sperm fish -- Radiation-induced transgenerational instability in mice -- New genetic information generated by endogenous reverse transcription in sperm cells -- Sperm abnormalities in exposed humans -- Oestrogenic compounds and oxidative stress -- DNA repair capacities in testicular cells of rodents and man -- Closing panel discussion.
This book was developed from the 3rd International Congress on Male-Mediated Developmental Toxicity held at the Bradford from 31st July to 3rd August, 2005. -- Preface.
Includes bibliographical references and index.
Keywords: Mutagenesis; Antibody diversity; Spermatogenesis -- drug effects -- Congresses; Antineoplastic Agents -- adverse effects -- Congresses; Environmental Exposure -- adverse effects -- Congresses; Genetic Predisposition to Disease -- Congresses; Mutagenesis -- Congresses; Neoplasms -- etiology -- Congresses; Pregnancy Outcome -- Congresses