Metal-carbon bonds in enzymes and cofactors - Sigel, Astrid; Sigel, Helmut; Sigel, Roland K. O. (Cambridge, UK RSC Pub., 2009)
Organometallic chemistry of B12 coenzymes -- Cobalamin- and corrinoid-dependent enzymes -- Nickel-alkyl bond formation in the active site of methyl-coenzyme M reductase -- Nickel-carbon bonds in acetyl-coenzyme a synthases/carbon monoxide dehydrogenases -- Structure and function of [NiFe]-hydro-genases -- Carbon monoxide and cyanide ligands in the active site of [FeFe]-hydrogenases -- Carbon monoxide as intrinsic ligand to iron in the active site of [Fe]-hydrogenase -- Dual role of heme as cofactor and substrate in the biosynthesis of carbon monoxide -- Copper-carbon bonds in mechanistic and structural probing of proteins as well as in situations where copper is a catalytic or receptor site -- Interaction of cyanide with enzymes containing vanadium, manganese, non-heme iron, and zinc -- Reaction mechanism of the molybdenum hydroxylase xanthine oxidoreductase: evidence against the formation of intermediates having metal-carbon bonds.
Includes bibliographical references and indexes.
Keywords: Metalloenzymes; Coenzymes; Organometallic compounds; Vitamin B12.; Coenzymes -- Chemistry; Organometallic Compounds -- Chemistry; Multienzyme Complexes -- Chemistry; Oxidoreductases -- Chemistry