00000cmm a22000004i 4500 UP-99796217611095164 Buklod 20140201102128.0 m go j cr |n |||auu|a 110503s2011 xxu u | eng d 9781441988317 (eBook) 1441988319 (iLib)UPD-00212404595 DLC DML eng DMLUC QH 205.2 C37 2011 Carlton, Robert Allen. author. Pharmaceutical microscopy [electronic resource] Robert Allen Carlton. New York Springer c2011. 1 online resource (xiv, 321 p.) ill. (some col.) Chapter 1: Introduction -- METHODS AND TECHNIQUES Chapter 2: Polarized Light Microscopy: Theory of PLM -- Polarized Light -- Optical Crystallography -- Types of Instruments -- Köhler Illumination -- Chapter 3: Thermal Microscopy -- Introduction -- Instruments and Methods -- Calibration -- Observations -- Exercises -- Chapter 4: SEM and EDS: Scanning Electron Microscopy -- Energy Dispersive X-ray Spectrometry -- Exercises -- Chapter 5: Microspectroscopy: Theory -- Infrared Microspectroscopy -- Raman Microspectroscopy -- Chemical Imaging -- Exercises -- Chapter 6: Other Types of Microscopy: Confocal Microscopy -- Atomic Force Microscopy -- Transmission Electron Microscopy -- DIC -- Phase contrast -- Dispersion staining -- Flourescence -- Freeze dry microscopy -- Chapter 7: Image Analysis: Digital Image Analysis -- Statistical Analysis -- Exercises (using ImageJ or Joys program) -- APPLICATIONS Chapter 8: Polymorphism: Theory -- Early Stage Development Studies -- Late Stage Development Studies -- Exercises -- Chapter 9: Size and Shape Analysis: Theory -- Sampling -- Comparison with other Techniques -- Automation -- Validation -- Exercises -- Chapter 10: Contaminant Analysis: General Approach -- Examples -- Exercises -- Chapter 11: Conclusion -- Chapter 12: References and Bibliography. IP-based subscription, access limited to within on-campus computer network. Access via Electronic Resources of the UPD University Library Website. Microscopy plays an integral role in the research and development of new medicines. Pharmaceutical Microscopy describes a wide variety of  techniques together with numerous practical  applications of importance in drug development. The first section  presents general methods and applications with an emphasis on the physical science aspects. Techniques covered include optical crystallography, thermal microscopy, scanning electron microscopy, energy dispersive x-ray spectrometry, microspectroscopy (infrared and Raman), and particle size and shape by image analysis. The second section presents applications of these techniques to specific topics of pharmaceutical interest, including studies of polymorphism, particle size and shape analysis, and contaminant identification.  Pharmaceutical Microscopy is designed for those scientists who must use these techniques to solve pharmaceutical problems but do not need to become expert microscopists.  Consequently, each section has exercises designed to teach the reader how to use and apply the techniques in the book.  Although the focus is on pharmaceutical development, workers in other fields such as food science and organic chemistry will also benefit from the discussion of techniques and the exercises. Provides comprehensive coverage of key microscopy techniques used in pharmaceutical development Helps the reader to solve specific problems in pharmaceutical quality assurance Oriented and designed for pharmaceutical scientists who need to use microscopy but are not expert microscopists Includes a large number of practical exercises to give the reader hands-on experience with the techniques Written by an author with 21 years of experience in the pharmaceutical industry. Electronic reproduction. New York SpringerLink 2011. Available via World Wide Web through SpringerLink. Microscopy. Drug development. Microscopy Technique. Electronic books. SpringerLink (Online service). Available for University of the Philippines Diliman via SpringerLink. Click here to access http://dx.doi.org/10.1007/978-1-4419-8831-7 (viewed 05 June 2014) FO Monograph UPD DMLR Electronic Resource