00000cmm a22000004i 4500 UP-99796217611094970 Buklod 20140129111316.0 m go j cr |n |||auu|a 110406s2011 xx u | eng d 9783211990797 (eBook) 3211990798 (eBook) (iLib)UPD-00212404346 DLC DML eng DMLUC QP 624.74 M47 2011eb Metallointercalators [electronic resource] synthesis and techniques to probe their interactions with biomolecules eJanice Aldrich-Wright, editor. Wien New York Springer c2011. 1 online resource (xxviii, 427p.) ill. (some col). Introduction -- Synthesis:Platinum Intercalating Complexes; Binuclear Platinum Complexes;Binuclear Ruthenium and Platinum Intercalating Complexes; Sequence Selective Intercalating Complexes; Targeting and Improving Transport, Cucurbit[n]uril, Cylcodextrin and Dendrimers -- Techniques to Probe Interactions with Biomolecules:Introduction to NMR; DNA-NMR; PGSE-NMR; DNA ESI-MS; Investigating Binding Interactions using Linear Dichromism and Circular Dichromism; Flourescence Spectroscopy; Confocal Microscopy; Implementation of synchotron X-ray microscopy for investigations of the cellular uptake and cellular metabolism of metallointercalators; Biomolecular Helical Structure; Viscosity, TGA and Dialysis; Microarrays; Cytotoxicity-Cell lines; Antibacterical activity; Animal testing. IP-based subscription, access limited to within on-campus computer network. Access via Electronic Resources of the UPD University Library Website. A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery. Electronic reproduction. New York SpringerLink 2011. Available via World Wide Web through SpringerLink. DNA-ligand interactions. Clathrate compounds. Transition metal complexes. Genetic regulation. Electronic books. Aldrich-Wright, Janice. SpringerLink (Online service). Available for University of the Philippines Diliman via SpringerLink. Click here to access http://dx.doi.org/10.1007/978-3-211-99079-7 (viewed 26 May 2014) FO UPD DMLR Electronic Resource