00000cmm a22000004i 4500 UP-99796217611094956 Buklod 20140129104705.0 m go j cr |n |||auu|a 110621s2011 xx u | eng d 9783642199226 (eBook) 3642199224 (eBook) (iLib)UPD-00212404329 DML eng DMLUC QH 603 I54 I563 2011eb Ion channels and their inhibitors [electronic resource] Satya Prakash Gupta, editor. Berlin, Heidelberg Springer Berlin Heidelberg 2011. 1 online resource (xiii, 348 p.) ill. (some col.) Structural and Functional Discrimination of Membrane -- Proteins -- Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels -- Advanced Molecular Modeling Techniques Applied to Ion Channels Blockers -- Advances in Design and Development of Sodium Channel Blockers -- Potassium Channel Blockers as Anti-arrhythmic Agents.-  hERG Potassium Channels in Drug Discovery and Development -- Prediction of hERG Channel Inhibition Using in silico Techniques -- Advances in Structure-Activity Relationship Studies on Potassium Channel Modulators -- Calcium Ion Channels and Their Blockers -- Therapeutic Potential of N-type Voltage Gated Ca2+ Channel -- Chloride Ion Channels: Structure, Functions, and Blockers. IP-based subscription, access limited to within on-campus computer network. Access via Electronic Resources of the UPD University Library Website. Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry. Electronic reproduction. New York SpringerLink 2011. Available via World Wide Web through SpringerLink. Ion channels. Electronic books. Gupta, Satya Prakash. SpringerLink (Online service). Available for University of the Philippines Diliman via SpringerLink. Click here to access http://dx.doi.org/10.1007/978-3-642-19922-6 (viewed 16 May 2014) FO Monograph UPD DMLR Electronic Resource