00000cmm a22000004i 4500 UP-99796217611094892 Buklod 20140129083435.0 m go j cr |n |||auu|a 110119s2011 xx u | eng d 9783642154737 (eBook) (iLib)UPD-00212404239 DLC DML eng DMLUC QD 401 O48 2011eb Ohta, Yusuke Copper-catalyzed multi-component reactions [electronic resource] synthesis of nitrogen-containing polycyclic compounds Yusuke Ohta. Berlin Heidelberg New York Springer c2011. 1 online resource (xvi, 104 p.) Springer theses. IP-based subscription, access limited to within on-campus computer network. Access via Electronic Resources of the UPD University Library Website. A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers. Electronic reproduction. New York Springerlink 2011. Available via World Wide Web through SpringerLink. Organonitrogen compounds. Polycyclic compounds Synthesis. Electronic books. SpringerLink (Online service). Available for the University of the Philippines Diliman via SpringerLink. Click here to access http://link.springer.com/book/10.1007/978-3-642-15473-7 (viewed 23 May 2014) FO Monograph UPD DMLR Electronic Resource