00000cmm a22000005i 4500 UP-99796217611094605 Buklod 20140127112635.0 m go j cr |n |||auu|a 101125s2011 xxu u | eng d 9781441972033(eBook) (iLib)UPD-00212403853 DLC DML eng DMLUC RC 262 S54 2011eb Glick, Adam B. editor. Signaling pathways in squamous cancer [electronic resource] Adam B. Glick, Carter Van Waes, editors. New York, NY Springer New York 2011. 1 online resource (xx, 462 p.) ill. IP-based subscription, access limited to within on-campus computer network. Access via Electronic Resources of the UPD University Library Website. Squamous epithelia form the essential lining surface of tissues in contact with the environment, including the skin, and mucosa of the oral cavity, pharynx, larynx, esophagus, respiratory and genital tracts, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV light, tobacco smoke, and infectious agents. Consequently, squamous cell carcinomas that form in these tissues are among the most common human solid tumors, and have high morbidity and mortality. The signaling pathways that regulate epithelial homeostasis and the alterations in these pathways that arise during cancer development share certain features among these different tissue sites. This book brings together timely reviews from experts in the field on mechanisms and signaling pathways such as EGFR, TGF?1, NF?B, PPARs and mTOR/AKT that regulate development of squamous cancer in both human and experimental mouse models, with a focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy. This comprehensive monograph will be important for researchers wishing to enter the field, for medical students, and for established basic and clinical investigators who would gain from an overview of the field. Electronic reproduction. New York SpringerLink 2011. Available via World Wide Web through Springerlink. Squamous cell carcinoma. Electronic books. Waes, Carter Van. editor. SpringerLink (Online service). Available for University of the Philippines Diliman via SpringerLink. Click here to access http://link.springer.com/book/10.1007/978-1-4419-7203-3 (viewed 19 May 2014) FO Monograph UPD DMLR Electronic Resource