00000cmm a22000001i 4500 UP-99796217611077449 Buklod 20140125090139.0 m go j cr |n |||auu|a 101109s2011 xxu u | eng d 9781441973689 (eBook) 1441973680 (eBook) (iLib)UPD-00211304483 DLC DML eng DMLUC QP 552 A27 N48 2011eb Neurobiology of actin [electronic resource] from neurulation to synaptic function Gianluca Gallo, Lorene M. Lanier, editors. New York Springer c2011. 1 online resource (viii, 282 p.) Advances in Neurobiology 2190-5215 5 Introduction to the Neurobiology of Actin -- The Neuronal Actin Cytoskeleton and the Protrusion of Lamellipodia and Filopodia -- Regulation of Actin Filaments During Neurite Extension and Guidance -- Functions of Myosin Motor Proteins in the Nervous System -- Microtubule-Actin Interactions During Neuronal Development -- Working with Actin: Methodological Approaches for the Study of Actin in Neurons -- Functions of the Actin Cytoskeleton in the Early Embryology of the Nervous System -- Actin Cytoskeletal Regulation in Neuronal Migration -- Actin and Neuronal Polarity -- Actin at the Synapse: Contribution to Pre and Post-synaptic Functions -- Actin and Diseases of the Nervous System -- Signal Transduction Pathways: From Receptor to the Actin Cytoskeleton. IP-based subscription, access limited to within on-campus computer network. Access via Electronic Resources of the UPD University Library Website. Neurons are characterized by a complex, dynamic and highly polarized morphology. Actin and its regulatory proteins are the most abundant set of proteins within cells, and they form one of the major cytoskeletal systems -- the actin filament cytoskeleton. While much has been learned about the roles of the actin cytoskeleton in non-neuronal cells, our understanding of the full spectrum of the functions of actin in neurons is far from complete. This book is an introduction to the interface between the actin cytoskeleton and the myriad of issues fundamental to the understanding of nervous system function. Neurobiology of Actin: From Neurulation to Synaptic Function opens with a chapter that presents the fundamental concepts required to appreciate the details of the molecular machinery that regulates actin in a cellular context, setting the stage for the first part of the book which reviews the neurobiology of actin at the cellular level. The second section of the book then discusses the functions of actin in the context of neurobiological issues ranging from early development to synaptic function and disease states of the nervous system. This text is intended for neuroscientists interested in investigating the actin cytoskeleton in the context of their particular neuroscience research program, and its chapters are cross-referenced in order to assist readers in finding relevant information that is covered in greater depth in other chapters. Electronic reproduction. New York SpringerLink c2011. Available via World Wide Web through SpringerLink. Actin. Neurobiology. Neurophysiology. Gallo, Gianluca. Lanier, Lorene M. SpringerLink (Online service). Advances in Neurobiology 2190-5215 54 Available for University of the Philippines Diliman via SpringerLink. Click here to access http://dx.doi.org/10.1007/978-1-4419-7368-9 (viewed 10 June 2014) FO Monograph UPD DMLR Electronic Resource