00000cmm a22000005i 4500 UP-99796217611000184 Buklod 20230504003249.0 m||||fo||d| |||||| cr cn ||||||aa 131120s xx d u 9783764389482 (eBook) (iLib)UPD-00206905128 DLC DML eng RC 280 B6 B67 2011eb Bortezomib in the treatment of multiple myeloma [electronic resource] edited by Irene M. Ghobrial, Paul G. Richardson, Kenneth C. Anderson. Basel Springer Basel c2011. 1 online resource (viii, 179 p.) IP-based subscription, on campus only. Access via Electronic Resources of the UPD University Library Website. Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry. Electronic reproduction. New York SpringerLink c2011. Available via World Wide Web through SpringerLink. Multiple myeloma Treatment. Multiple myeloma Chemotherapy. Antineoplastic agents. Boronic Acids Therapeutic use. Multiple myeloma Drug therapy. Antineoplastic agents Therapeutic use. Protease inhibitors Therapeutic use. Proteasome endopeptidase complex Antagonists & inhibitors. Pyrazines Therapeutic use. Electronic books. Ghobrial, Irene M. Richardson, Paul G. Anderson, Kenneth C. SpringerLink (Online service). Springer eBooks. Electronic Resource http://link.springer.com/book/10.1007/978-3-7643-8948-2 Available for University of the Philippines Diliman via SpringerLink. Click here to access (viewed 3 April 2014) FO Monograph UPD DMLR Electronic Resource