A prototype for unsupervised analysis of tissue microarrays for cancer research and diagnostics.

The tissue microarray (TMA) technique enables researchers to extract small cylinders of tissue from histological sections and arrange them in a matrix configuration on a recipient paraffin block such that hundreds can be analyzed simultaneously. TMA offers several advantages over traditional specime...

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Bibliographic Details
Published in:	IEEE Transactions on information technology in biomedicine 8, 2 (2004).
Main Author:	Wenjin Chen
Format:	Article
Language:	English
Subjects:	Automated imaging. Breast cancer. Cancer diagnostics. Color decomposition approach. Image registration. Immunohistochemical expression level. Malignancy. Matrix configuration. Microscope. Molecular target. Multiuser network environment. Protein expression profile. Recipient paraffin block. Review. Specimen preparation. Staining signature. Tissue microarray. Unsupervised analysis. Web-based prototype.