Molecular imaging and therapy directed at the neovasculature in pathologies.

This paper discussed the impact of molecular imaging on clinical and preclinical medicine. Potential problems of delivering the effective therapeutic dose and the properties that can help contribute to the drug efficacy were presented. The rationale for the design of new antiangiogenic agents that c...

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Bibliographic Details
Published in:	IEEE Engineering in medicine and biology magazine 23, 5 (2004).
Main Author:	Guccione, S.
Format:	Article
Language:	English
Subjects:	spl alpha//sub v//spl beta//sub 3/ integrin expression. MRI. V2 carcinoma. Anti-/spl alpha//sub v//spl beta//sub 3/-targeted polymerized vesicles. Antiangiogenic agents. Antiangiogenic gene delivery system. Clinical medicine. Drug efficacy. Gadolinium. In vivo angiogenic tumor imaging. Molecular imaging. Murine antibody LM609. Nanoparticle-based therapies. Neovasculature. Preclinical medicine. Rabbits. Targeted contrast agent. Therapy. Tumor-associated vasculature.