00000nam a22000004a 4500 UP-8027390931316423414 Buklod 20251001115024.0 m |o d | ta 250924s2025 xxu r |||| u|eng d PHARM rda eng LG 993.5 2025 P5 E63 Epan, Adriel Christianne H. author Preformulation studies of crude ethanolic extract from the leaves of mentha x villosa huds. for the development of a matrix-type transdermal system Adriel Christianne H. Epan, Angelyn O. Rafael ; Jocelyn S. Bautista-Palacpac, adviser. Manila College of Pharmacy, University of the Philippines Manila 2025 xii, 87 leaves 28 cm. Thesis (Bachelor of Science in Pharmaceutical Sciences)--University of the Philippines Manila, June 2025 Available only after consultation with author/thesis adviser Mentha x villosa Huds, commonly known as Yerba Buena, is one of the “Sampung Halamang Gamot” endorsed by the Department of Health for its traditional use for pain relief. This study aimed to prepare a preformulation report for the crude ethanolic leaf extract of M villosa for the development of a matrix-type transdermal system through characterization of M villosa powdered leaves and crude extracts and stability testing. The characterization was done through organoleptic and physicochemical evaluations and pharmacopeial tests. The stability of M villosa Huds crude extract alone, in the presence of moisture, and in combination with excipients were tested under different temperature conditions, control (4oC), room temperature (29oC), and elevated temperature (40oC). The M villosa powdered leaves met the specified acceptable limits for all pharmacopeial tests, including Total Ash Content, Acid-Insoluble Ash, Loss on Drying, Hygroscopicity and Total Extractives. Based on organoleptic evaluation, M. villosa crude extract was found to be a dark green, sticky liquid with a minty scent and a smooth, viscous texture. The consistency of M villosa crude extract could pose challenges in formulation, making it less suitable as an active ingredient without further processing. The crude extract consistently showed an acidic pH and contained polyphenols and flavonoids, as confirmed by physicochemical evaluation. Moreover, stability studies indicated that M villosa crude extract maintained its stability, when tested alone, in the presence of moisture, and when combined with the selected excipients, under controlled and room temperature conditions but showed changes in stability at elevated temperature. Transdermal drug delivery systems Preformulation Plant extracts Mentha ×villosa. Matrix systems (Pharmacy) Ethanolic extracts Herbal medicine. Medicinal plants Leaves Therapeutic use Pharmaceutical technology. Mentha x villosa Huds. crude extract. Preformulation Studies, Stability Studies. Preformulation Studies. Stability Studies. Rafael, Angelyn O. author . Bautista-Palacpac, Jocelyn S. adviser. FI UP UPMNL PHARM LG 993.5 2025 P5 E63 Thesis