00000nam a22000004a 4500 UP-8027390931316421944 Buklod 20251001114815.0 m |o d | ta 250924s2025 xxu r |||| u|eng d PHARM rda eng LG 993.5 2025 P5 C37 Carlos, Sophia Isabelle R. author One-factor-at-a-time-guided development of simvastatin-loaded alginate-chitosan microspheres Sophia Isabelle R. Carlos, Aianna Jennine R. Goyena, Joana Pauline L. Honasan ; Bryan Paul I. Bulatao, adviser ; Julius Andrew P. Nuñez, co-adviser . Manila Department of Industrial Pharmacy, College of Pharmacy, University of the Philippines Manila 2025 xii, 166 leaves 28 cm. Thesis (Bachelor of Science in Pharmaceutical Chemistry)--University of the Philippines Manila, July 2025 Available only after consultation with author/thesis adviser Pursuant to the concept of quality by design, recent trends in polymer-based drug delivery system research utilize design of experiments (DOE) to systematically identify factor levels that yield optimal responses. One-factor-at-a-time (OFAT) guided experiments remain useful in providing a basis for these DOE studies, particularly for the low and high levels of the factors they can use for optimization. This study employed this approach to fabricate microspheres loaded with simvastatin (SMV) in attempt to address the bioavailability issues of the drug brought by its premature metabolism in the gastrointestinal tract. SMV concentration (Factor 1), polymer (ALG:CS) ratio (Factor 2), and crosslinker (CaCl2) concentration (Factor 3) were evaluated individually in terms of their effect on particle size, encapsulation efficiency (%EE), and loading capacity (%LC). Initial assessments were performed with three levels, followed by the addition of other levels necessary for further analysis. All three factors showed parabolic effects in relation to %EE and %LC. For particle size, Factor 1 and 3 generally showed a linear relationship with indications of plateauing. Factor 2 demonstrated a curved trend, though it is not conclusive of a parabolic effect. In consideration of these observations supported by statistical analyses, the study proposed low and high values of these factors which can be used for studies aiming to optimize the formulation. Drug delivery systems Microspheres Alginate-chitosan Simvastatin. Controlled release preparations Experimental design One-factor-at-a-time method. Simvastatin Pharmaceutical formulation Biopolymer-based microspheres. simvastatin. OFAT. microspheres. particle size. encapsulation efficiency. loading capacity. Goyena, Aianna Jennine R. author . Honasan, Joana Pauline L. author . Bryan Paul I. Bulatao adviser. Julius Andrew P. Nuñez co-adviser. FI UP UPMNL PHARM LG 993.5 2025 P5 C37 Thesis