00000ctm a22000003a 4500 UP-8027390931314102208 Buklod 20240401151751.0 m |o d | ta 240401s xx d r |||| u| (iLib)UPVIS-00163755831 gift VML/ess 04.01.2024 eng LG 993.5 2024 E62 M363 Malagum, Sanny D. Jr. Pectin-based composite scaffolds a review on fabrication, characterization, and bone tissue engineering applications. 2024. xiii, 267 leaves. text rdacontent unmmediated rdamedia volume rdacarrier Thesis (Undergraduate, Bachelor of Science in Chemical Engineering) School of Technology, University of the Philippines Visayas, Miagao, Iloilo. 2024. Bone defects pose significant human challenges, causing disability and substantial social and economic burdens. While minor defects frequently undergo natural self-repair, critical bone defects necessitate clinical intervention. Conventional bone reconstructive procedures, which entail the use of bone grafts, face crucial drawbacks. These include limited availability, infection risks, immune rejection, donor site complications, and the need for additional surgical procedures. Fortunately, bone tissue engineering (BTE), which centers on designing scaffolds that support bone regeneration, offers a promising alternative. Pectin, a heteropolysaccharide derived from terrestrial plants, has been gaining considerable attention as a scaffold material due to its non-toxic nature and degradability. Considering these favorable aspects of pectin, this review paper examined the fabrication, characterization, and BTE applications of pectin-based composite scaffolds. Significantly, pectin's anionic molecular structure enables it to form composite scaffolds with other materials.Specifically, the carboxyl groups within pectin readily create linkages with amino groups in these materials. Noteworthy, pectin-based composites exhibited strong biocompatibility with both bone and stem cells. In vivo studies have further illuminated their capacity to foster new bone formation in animal models. Additionally, pectin boasts biodegradability under physiological conditions, a feature of utmost importance eliminates the necessity for implant removal surgeries. Nevertheless, extensive in vivo assessments, well-defined translation strategies, and rigorous clinical validation are indispensable to fully unlock the potential of pectin in bone tissue regeneration applications. By aligning research with translational needs, these innovative scaffolds promise to reinforce solutions in BTE, enhancing patient outcomes. Bone tissue engineering. Nava, Juniper V. Magallanes Thesis adviser. FI UPVIS UPV-SOTECH LG 993.5 2024 E62 M363 Thesis