00000nam a22000008i 4500 UP-1685954869149783447 Buklod 20240807081744.0 m |o d | cr ||||||||||| 240807s2021 nyu u eng 9783030638177 (eBook) 21613025 DLC DENGII rda eng R 857.M3 J67 2021eb Joshi, Rucha author. Collagen biografts for tunable drug delivery Rucha Joshi. First edition. Cham, Switzerland Springer Cham [2021] 1 online resource text txt rdacontent computer rdamedia online resource cr rdacarrier SpringerBriefs in Applied Sciences and Technology IP based subscription, on campus and remote access Access via Electronic Resources of the UPD Engineering Library and University Library websites. This book reviews collagen-based biomaterials that have been applied broadly to tissue engineering and local drug delivery applications and lays out a landscape for developing a multifunctional biograft material from collagen polymers. The book also discusses current shortcomings in collagen based drug delivery opportunities, including poor mechanical properties, rapid proteolytic degradation, and cursory control over physical properties and molecular release profiles. Finally, a review of application of the collagen biograft materials for promoting neovascularization and tissue regeneration is presented, using examples of established in-vivo chicken egg chorioallantoic membrane (CAM) model. Use of heparin for affinity-based vascular endothelial growth factor (VEGF) retention in collagen constructs is also discussed for promoting neovascularization. Reviews state-of-the-art strategies for drug incorporation and retention in collagen ; Covers collagen based material applications for improving vascularization and tissue regeneration; Illustrates how to tailor collagen architecture for soft tissue engineering and controlled drug delivery. Electronic reproduction Cham, Switzerland Springer Cham 2021 Available via World Wide Web through SpringerLink. Collagen Therapeutic use. Biomedical materials Therapeutic use. Available for University of the Philippines System via SpringerLink. Click here to access https://doi.org/10.1007/978-3-030-63817-7 Also available remotely for the University of the Philippines System via SpringerLink. Click here to access thru EZproxy https://link-springer-com.ezproxy.engglib.upd.edu.ph/book/10.1007/978-3-030-63817-7 FO UPD DENG-II R 857.M3 J67 2021eb Electronic Resource