00000ctmaa22000004a 4500 UP-1685675941123958174 Buklod 20180806163656.0 aa rb |||1 u| ta 181005s2018 xx bf rb |000 0|eng d (iLib)UPTAC-00019010285 UPVTC eng LG 993.5 2018 B5 A27 Abrenio, Romajane V. author. Antidiabetic activity of Doña Luz (Mussaenda erythrophylla) and Doña Aurora (Mussaenda philippica) leaf methanolic extracts using zebrafish (Danio rerio) as a model Romajane V. Abrenio; Rolly G. Fuentes, adviser. Tacloban City Romajane V. Abrenio 2018. iv, 27 leaves illustrations 30 cm. text rdacontent unmediated rdamedia volume rdacarrier Undergraduate thesis [Bachelor of Science (Biology)]--University of the Philippines Visayas Tacloban College, June 2018. Permission is given to the general public to have access to this research. Diabetes mellitus is one of the most prevalent metabolic problem worldwide. It is rapidly increasing, leading to microvascular and macrovascular diseases. In this study, antidiabetic effects of the crude extracts of selected shrub series namely Mussaenda erythrophylla and Mussaenda philippica were detected using zebrafish as the model organism. During the detection process, 1 ug/g dosage of the extracts were applied on the zebrafish after inducing the adult zebrafish in a hyperglycemic state using alloxan and glucose solution. The blood glucose level of zebrafish were taken at 0, 90, and 180 min afterwards. Preliminary phytochemical screening were conducted thereafter to test the presence or absence of the phytochemical compounds that were proven to be anti-hyperglycemic. One-way ANOVA revealed that the mean difference of the blood glucose level (BGL) decrease of the extracts from metformin was statistically significant (F(3,40)= 6.212p < 0.001). In line with this, results showed that both extracts have anti-hyperglycemic effect on the zebrafish as there was a reduction in the mean BGL after 90 min of glucose loading. Further decrease was observed as the time progressed to 180 minutes. Between the two extracts, M. erythrophylla displayed a higher decrease in the mean BGL than M. philippics. M. erythrophylla also showed similar results in the decrease of the BGL with the antidiabetic drug, metformin, indicating its potency against the metabolic disease. Hypoglycemic agents. Phytochemicals. Diabetes Treatment. Fuentes, Rolly G. adviser. FI UP UPTAC UPTAC LG 993.5 2018 B5 A27 Thesis