00000cam a22000004a 4500 UP-1685675941123940534 Buklod 20170207091039.0 aa rb |||1 u| ta 050920s2016 xx a rbf |001 0|eng d 9780128038932 (iLib)UPTAC-00018523916 Tac-20143 Mega Texts Php8,530 UPVTC eng QD 261 I83 2016 Isac-Garcia, Joaquín author. Experimental organic chemistry laboratory manual Joaquín Isac-García, José A. Dobado, Francisco G. Calvo-Flores, Henar Martínez-García. London Academic Press [2016] xii, 488 pages illustrations text rdacontent unmediated rdamedia volume rdacarrier Includes bibliographical references and index. Table of Contents: Preface. -- 1. Laboratory Safety: 1.1 The lab as a safe place -- 1.2 Personal protective equipment -- 1.3 Emergency equipment for general purpose -- 1.4 GHS tor classification and labeling of chemicals -- 1.5 Chemical incompatibility and storage -- 1.6 Substances with risk of fire and explosion -- 1.7 Waste treatment and disposal -- 1.8 References. -- 2. Lab Notebook: 2.1 Notebook structure -- 2.2. Experiment report for a practice course -- 2.3 Some guidelines for keeping a notebook -- 2.4 Example of an experiment description -- 2.5 Basic calculations. -- 3. Laboratory Equipment: 3.1 Introduction -- 3.2 Manufacture of lab equipment -- 3.3 Cleaning of glassware -- 3.4 General-purpose glassware -- 3.5 Fastening and anchoring -- 3.6 Pressure and vacuum equipment -- 3.7 Pressure reactors and hydrogenators -- 3.8 Other materials. -- 4. Basic Laboratory Operations: 4.1 Introduction -- 4.2 Weighing of solids and liquids -- 4.3 Measurement of liquid volumes or solutions -- 4.4 Transfer of solids and liquids -- 4.5 Techniques used in chemical reactions -- 4.6 Reflux -- 4.7 Isolation and purification of solids -- 4.8 Liquid-liquid extraction -- 4.9 Solid-liquid extraction (Soxhlet) -- 4.10 Removal of solvents under reduced pressure -- 4.11 Distillation -- 4.12 Reactions in an inert atmosphere -- 4.13 Reaction and removing of gaseous products -- 4.14 Chromatographic techniques -- 4.15 References. -- 5. Determining Physical and Spectroscopic Properties: 5.1 Introduction -- 5.2 Determining physical properties -- 5.3 Determining spectroscopic properties -- 5.4 Preparation of samples for spectroscopy. -- 6. Functional-Group Analysis: 6.1 Introduction -- 6.2 Qualitative elemental analysis -- 6.3 Organoleptic and physical properties -- 6.4 Classification by solubility (solubility tests) -- 6.5 Functional-group analysis -- 6.6 Identification of an unknown substance -- 7. Basic Operation Experiments: 7.1 Recrystallization and solubility tests -- 7.2 Stirring and decanting -- 7.3 Simple distillation -- 7.4 Extraction and "rotary evaporator" -- 7.5 Liquid-liquid extraction (with centrifuge) -- 7.6 Liquid-liquid extraction (with separatory funnel) -- 7.7 Reflux, simple, and fractional distillation -- 7.8 Steam distillation and vacuum distillation -- 7.9 Solid-liquid extraction (Soxhlet) -- 7.10 TLC and CC chromatography -- 7.11 References -- 8. Organic Synthesis Experiments: 8.1 Alkene oxidation -- 8.2 Dehydration of alcohols -- 8.3 Oxidation of alcohols -- 8.4 Nucleophilic substitution reactions -- 8.5 Synthesis of an ether -- 8.6 Aromatic electrophilic substitution of an ester -- 8.7 Electrophilic aromatic substitution (SeAr) -- 8.8 Synthesis of azo dyes -- 8.9 Auto-oxidation reduction of aromatic aldehydes -- 8.10 Synthesis of a, B-unsaturated ketones -- 8.11 Saponification reaction -- 8.12 Esterification -- 8.13 Disfunctional compound chemoselectivity -- 8.14 Perkin reaction -- 8.15 Synthesis of imide -- 8.16 Condensation polymerization reaction -- 8.17 Radical polymerization -- 8.18 Multistep synthesis of a drug -- 8.19 Multistep synthesis of an anesthetic -- 8.20 Using protecting groups -- 8.21 References -- 9. Advanced Organic Synthesis Experiments: 9.1 Reductive amination. 9.2 Chiral resolution. 9.3 Stereospecific synthesis of glycols. 9.4 Reactivity of carbenes. 9.5 Regioselective halogenations. 9.6 Oxidative coupling of alkynes. 9.7 Diels-Alder reactions. 9.8 Wittig reaction. 9.9 Grignard reagents. 9.10 Organometallic compounds. 9.11 Chemoselectivity. 9.12 Electrophilic aromatic substitution (SeAr) -- 9.13 Hofmann rearrangement -- 9.14 Radical coupling -- 9.15 Synthesis of a heterocyclic drug -- 9.16 Transformations of hydroxy ketone -- 9.17 Enamines as reaction intermediates -- 9.18 N-Heterocycle synthesis -- 9.19 Synthesis of macrocycles -- 9.20 Preparation of a sports dietary supplement -- 9.21 Claisen condensation -- 9.22 Terpene transformation -- 9.23 Carbohydrates -- 9.24 Preparation of a nucleoside -- 9.25 References -- 10. Microscale: 10.1 Introduction -- 10.2 The scales in the Organic Chemistry laboratory -- 10.3 Pros of working at the microscale -- 10.4 Specific microscale lab equipment -- 10.5 Microscale laboratory techniques -- 10.6 References -- 11. Microscale Experiments: 11.1 Addition of HX to alkenes -- 11.2 Production of margarine -- 11.3 Isomerization of alkenes -- 11.4 Nucleophilic substitution reaction -- 11.5 Methylketone reactivity -- 11.6 Electrophilic aromatic substitution (SeAr) -- 11.7 Sandmeyer reaction -- 11.8 Synthesis of a carbohydrate derivative -- 11.9 Free-radical halogenation -- 11.10 Alkylbenzene oxidation -- 11.11 Reduction of anthraquinonoid -- 11.12 Compounds for the fragrance industry -- 11.13 Tandem transesterification-esterification -- 11.14 Polyfunctional molecule reactivity -- 11.15 Multistep synthesis of n-heterocycles -- 11.16 Synthesis of five-membered heterocycles -- 11.17 References -- 12. Green Chemistry: 12.1 Introduction -- 12.2 The 12 principles of Green Chemistry -- 12.3 Goals of Green Chemistry -- 12.4 Parameters to evaluate chemical processes -- 12.5 Green Chemistry for undergraduate laboratories -- 12.6 References -- 13. Green Chemistry Experiments: 13.1 Oxidative cleavage of alkenes -- 13.2 Halogen addition to alkenes -- 13.3 Green epoxidation -- 13.4 Acylation of aromatic amines -- 13.5 Solvent-free reductive amination -- 13.6 Friedel-crafts alkylation -- 13.7 Regiospecific nitration of phenols -- 13.8 Oxidation of aromatic aldehydes -- 13.9 Green synthesis of ethers -- 13.10 Synthesis of an acetal in water -- 13.11 Reduction of a ketone alkaline solution -- 13.12 Solvent-free Baeyer-Villiger reaction -- 13.13 Enzymatic reduction of B-ketoesters -- 13.14 C-C Bond forming -- 13.15 C=C Bond formation in the absence of solvent -- 13.16 Diels-Alder in water -- 13.17 Green synthesis of a p-cymene -- 13.18 Oxidative coupling reaction in water -- 13.19 Organic compounds from recycled polymer -- 13.20 Crosslinked biodegradable polymers -- 13.21 Polymers from renewable raw materials -- 13.22 Organocatalysis -- 13.23 Knoevenagel-Pinner reactions in water -- 13.24 Biginelli reaction -- 13.25 Multi-component synthesis in water -- 13.26 Preparation of a dipyrrol derivative in water -- 13.27 Ionic liquid in water -- 13.28 Beckmann rearrangement -- 13.29 Fluorescent natural product -- 13.30 Photochemical solid phase -- 13.31 References. -- Index. Chemistry, Organic Experiments Laboratory manuals. Dobado, José A. author. Calvo-Flores, Francisco G. author. Martínez-García, Henar author. Table of contents https://drive.google.com/file/d/1-_Q9eK1_uL4G_0T2ZaVMyYgJ4-yRY5us/view?usp=sharing FO UPTAC UPTAC QD 261 I83 2016 Book