00000ctmaa22000003a 4500 UP-1685675941123923407 Buklod 20151021105128.0 aa rb |||1 u| ta 151021s xx d r |||| u| (iLib)UPTAC-00017741577 UPVTC eng LG 993.5 2011 B5 F47 Ferreras, Ma. Chrischelle A. author. Preliminary assessment of the diuretic activity of Hydrocotyle vulgaris methanolic extract in albino mice Ma. Chrischelle A. Ferreras; Teresa S. Mahinay, adviser. 2011. viii, 32 leaves illustrations. Undergraduate thesis (B.S. Biology) -- University of the Philippines, Tacloban. This study assessed the diuretic potential of methanolic extract of Hydrocotyle vulgaris in albino mice after oral administration. Methanolic extract of H. vulgaris (40 and 20 mg/kg) and the reference drug, Furosemide (20mg/kg) were administered intraperitoneally using modified Lipschitz method. All animals were pretreated with saline before commencing to experiment. Their urine output and electrolyte changes were quantitated at several intervals of time after the dose of 5 hours and after 24 hours. The urine output increased significantly in Furosemide and in both 40 and 20 mg/kg extracts (p<0.05). Methanolic extract of H. vulgaris increased the urine volume and electrolyte balance in a dose dependent manner and qualitatively similar to that of Furosemide. These findings collectively indicate that the extract exhibited significant diuretic activity, providing evidence, at least in part, for its traditional use as a diuretic. Science and Technology. Mahinay, Teresa S. author. FI UP UPTAC UPTAC LG 993.5 2011 B5 F47 Thesis