00000ctmaa22000001a 4500 UP-1685675941123907884 Buklod 20230928131223.0 aa rb |||1 u| ta 230928s2010 xx d |||| || | (iLib)UPTAC-00016219008 UPVTC rda eng LG 993.5 2010 B5 G67 Gorgonio, Stan Rey P. author. Antidiarrheal activity of methanolic leaf and bark extracts of cinnamomum mercadoi vidal. Tacloban City Stan Rey P. Gorgonio 2010 35 leaves illustrations. text rdacontent unmediated rdamedia volume rdacarrier Undergraduate thesis (B.S. Biology)--University of the Philippines, Tacloban The antidiarrheal activity of the leaves and bark of C. mercadoi Vidal (CMV-M) was evaluated on experimental diarrhea models in mice. The methanolic leaf and bark extract of C. mercadoi Vidal (250 and 500 mg/kg body weight) were administered by orogastric gavage to four groups of mice (five animals per group) in order to evaluate the activity of the extract against castor oil-induced diarrhea in mice. Two control groups were prepared: one received distilled water (10ml/kg) as negative controland the other loperamide (3mg/kg) as positive control. The effect of the extract on normal intestinal transit was assessed by gastrointestinal (GI) motility test via charcoal meal marker. In the mice with castor oil-induced diarrhea, at oral dose of 250 and 500 mg/kg body weight, the bark extract showed pronounced and dose-dependent antiddiarrheal activity. The protective role of the bark extract at 500 mg/kg was more than that of the reference drug, loperamide (3mg/kg). The bark extract (500mg/kg) produced a decrease in intestinal transit comparable to loperamide (3mg/kg) at p<0.05 level of significance. Although the leaf extracts inhibited an inhibitory effect on castor oil-induced diarrhea and GI motility test, the results were not significantly different from the negative control group. The inhibitory effect of the bark extract (CMV-M) on castrol oil induced diarrhea model and gastrointestinal motility induced diarrhea model and gastrointestinal motility test provides pharmacological evidence of its antidiarrheal activity. FI UP UPTAC UPTAC LG 993.5 2010 B5 G67 Thesis