00000caa a22000003i 4500 UP-1685594773862408674 Buklod 20210407210823.0 m | | ta 210407s2020 xx r |||| u|eng d (iLib)UPBAG-00039679835 STII-DOST BAG rda eng ARTICLE-3004 Reganit, Paul Ferdinand M. author. BAG6 variant rs805303 is nominally associated with acei-induced cough among Filipinos by Paul Ferdinand M. Reganit, Jose B. Nevado Jr., Eva Maria C. Cutiongco ? de la Paz, Jezreel L. Taquiso, Aimee Yvonne Criselle L. Aman, Elmer Jasper B. Llanes, Jose Donato A. Magno, Deborah Ignacia D. Ona, Felix Eduardo R. Punzalan, Lourdes Ella G. Santos, Richard Henry P. Tiongco II, Jaime M. Aherrera, Lauro L. Abrahan IV, Charlene F. Agustin, Adrian John P. Bejarin, and Rody G. Sy. 2020. pages 35-41 illustration 26 cm text rdacontent unmediated rdamedia volume rdacarrier Includes bibliographical references (pages 40-41) Cough is a common side effect of angiotensin converting enzyme inhibitor (ACEi) therapy. The incidence of ACEi-induced cough has been shown to correlate with genetic variation among different populations. This study aimed to determine the association of candidate genetic polymorphisms with ACEi-induced cough among Filipinos. Two hundred twenty (220) participants on ACEi therapy pressure-lowering in an unmatched case-control study (82 cases with ACEi-induced cough and 138 controls). Genomic DNA samples were extracted and genotyped for selected genetic variants. The association of genetic variants and clinical factors with ACEi-induced cough was determined using regression analyses. Univariate logistic regression showed that the BAG6 variant rs805303 is nominally associated with ACEi-induced cough among Filipinos, at a per-comparison error rate (PCER) of 0.05 (OR 2.10, p = 0.016). The association of the variant with ACEi cough was statistically significant after multiple regression analysis (adjusted OR 2.09, p = 0.022) while adjusting for confounding clinical factors (sex, alcohol intake, and diastolic blood pressure). Further studies are needed to validate these findings. (Author's abstract) Angiotensin converting enzyme inhibitor. BAG6. Cough. Filipino. rs805303. Nevado Jr., Jose B. author. Cutiongco ? de la Paz, Eva Maria C. author. Taquiso, Jezreel L. author. Aman, Aimee Yvonne Criselle L. author. Llanes, Elmer Jasper B. author. Magno, Jose Donato A. author. Ona, Ignacia D. author. Punzalan, Felix Eduardo R. author. Santos, Lourdes Ella G. author. Tiongco II, Richard Henry P. author. Aherrera, Jaime M. author. Abrahan IV, Lauro L. author. Agustin, Charlene F. author. Bejarin, Adrian John P. author. Sy, Rody G. author. The Philippine Journal of Science Vol. 149, no. 1, March 2020. Request full-text access via UPB University Library through https://forms.gle/KZjBv7aRtY6jiL5E9 (viewed 07 April 2021) FI UPBAG UPBAG-MAIN ARTICLE-3004 Analytics