In silico studies on N- (Pyridin-2-yl) Thiobenzamides as NNRTIs against wild and mutant HIV-1 strains

In silico studies on N- (Pyridin-2-yl) Thiobenzamides as NNRTIs against wild and mutant HIV-1 strains

In the present study, keeping the Lipinskiâ??s Rule of Five in focus, a series of new 4-(4-benzenesulfonylamino)-N-(5-substituted-pyridin-2-yl)-thiobenzamides bearing different substituents at the C-4 position of benzenesulfonylamino ring have been designed as NNRTIs of wild-type (WT) and mutant HIV...

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Hlavní autoři: Singh, Anuradha (Autor), Singh, Vishal Kumar (Autor), Verma,Rajesh (Autor), Singh, Ramendra K. (Autor)
Médium: Analytics
Jazyk:English
Vydáno: 2018.
Témata:
Chemistry.
Lipinski?s rule of five.
Hiv-1 reverse transcription.
Structure-activity relationships (sars).
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