00000caa a22000003i 4500 UP-1685594773862388186 Buklod 20210304144222.0 m | | ta 210304s1986 xx r |||| u|eng d (iLib)UPBAG-00039402973 STII-DOST BAG rda eng ARTICLE-2428 Fojas, Felicita R. author. Pharmacological studies on Jatropha curcas as a possible source of anti-arrythmic (Beta-blocker) agent by Felicita R. Fojas, L. L. Garcia, E. L. Venzon, B.A. Villanueva, A. J. Fojas and I. Llave. 1986. pages 317-328 illustrations 26 cm text rdacontent unmediated rdamedia volume rdacarrier Includes bibliographical references (page 321-322)and index. Preliminary pharmacological studies of Jatropha curcas Linn. or "tubang bakod" leaves suggest that this plant has potent cardiovascular action and is a possible source of an anti-arrhythmic (beta blocker) agent. Experiments on guinea pig showed decreased heart force (negative inotropic), decreased heart rate (negative chronotropic) and blocking of the isoprenaline stimulation responses on the auricle which is somewhat similar to a well-known beta-blocker, propranolol. Other findings indicate that the plant is a central depressant with some sympathomimetic activity and a potent drug with LD50 values of: 24.5 g/kg (18.15 g/kg - 33.08 g/kg) and 750 mg/kg (517 mg/kg - 1087 mg/kg), for the acqueous extract (decoction) and methanol extract, respectively. Pharmacology. Jatropha curcas Antiarrythmic properties. Botany, Medical. Tubang-bakod. Garcia, L.L. author. Venzon, E.L. author. Villanueva, B.A. author. Fojas, A.J. author. Llave, I. author. The Philippine Journal of Science Vol. 115, no.4, October-December 1986. Request full-text access via UPB University Library through https://forms.gle/KZjBv7aRtY6jiL5E9 (viewed 04 March 2021) FI UPBAG UPBAG-MAIN ARTICLE-2428 Analytics