00000cmm a22000003i 4500 UP-1685594773862075463 Buklod 20170314151818.0 g||| | || || ta 170314s2013 xx u eng d 9780124165700 (ebook) (iLib)UPBAG-00023564295 DLC BAG rda eng BC-ebook Sherbet, G. V. (Gajanan V.) author. Therapeutic strategies in cancer biology and pathology [electronic resource] Gajanan V. Sherbet. Amsterdam Elsevier [2013] 1 online resource (xxii, 288 pages) illustrations text txt rdacontent computer rdamedia online resource cr rdacarrier Elsevier insights. Includes bibliographical references. Introduction; 1: RNA Interference in Genetic Regulation; 1 The Biogenesis and Functions of MicroRNAs; 2 Association of miRNAs with Pathogenesis; The Genesis of DiGeorge Syndrome; Association of the Glyoxalase Pathway with miRNA Function; 3 Are miRNAs Suitable Targets for Cancer Therapy?; A Resumâe of mTOR Signalling; miRNAs, Cell Proliferation and Apoptosis; miRNAs in EMT, and Cell Motility and Invasion; miRNAs and Tumour Angiogenesis. 3: Therapeutic Deployment of Metastasis-Associated Gene Function9 S100A4 as a Potential Target; The Spectrum of Biological Function of S100A4; Influence of Wnt Signalling on S100A4 Expression; Osteopontin an Intermediary Target of S100A4; RAGE/NF-kB Signalling in S100A4 Function; S100A4 Downregulates PRDM1 and VASH1 Suppressor Genes; S100A2 Suppressor Gene and S100A4 Function; 10 MTAs in Cancer Invasion and Metastasis; The Biology of Metastasis Promotion by MTAs; Modulation/Inhibition of MTA Expression; MTA Signalling Intercalates with Wnt/Notch/Hh Signalling. 4: Genetic Determinants of Tumour and Metastasis Suppression11 Metastasis Suppressor nm23 and Manipulation of its Expression; Manipulation of nm23 Expression as a Therapeutic Approach; Upregulation of nm23 by Medroxyprogesterone Acetate; Targeting S100A4 to Restore nm23 Function; Is Tumour Suppressor p53 a Route to nm23 Manipulation?; 12 The Metastasis Suppressor KiSS-1 Gene; The Tumour Suppressor Function of Kisseptin; Kisseptin in Clinical Medicine; 13 KAI1 (CD82) Suppresses Metastasis, Cell Proliferation and Invasion; 14 14-3-3 Proteins in Normal and Tumour Cell Biology. MiRNAs, Tumour Growth, Invasion and MetastasisThe Influence of miRNAs on Metastasis Suppressors; miRNAs and Tumour/Metastasis Promoter Genes; miRNAs and Chemo/Radiosensitivity of Tumours; The Therapeutic Potential of miRNAs; 2: EMT Associated Gene Targeting; 4 Hedgehog Signalling in EMT; 5 Targeted Inhibition of Hh, Wnt, TGF-[beta] Signalling Complex; SMO Is a GPCR Component of Hh Signalling; Small Molecule Inhibitors of SMO; HDAC Inhibitors Combination with Hh Inhibition; Targeting Gli1 in Deregulated Hh Signalling; 6 Encountering Aberrant Wnt Signalling. The Canonical and Non-canonical Wnt Routes of SignallingFzd and LRP Inhibition, Dkk and SFRPs; Fzd and DVL Interaction; 7 Therapeutic Targeting of TGF-[beta] Signalling; Antisense Oligonucleotide Trabedersen (AP 12009); Anti-TGF-[beta] Monoclonal Antibodies; Lerdelimumab, Metelimumab and Fresolimumab; Small Molecule Inhibitors of the TGF-[beta] Receptor Family; Inhibition of Type RIII Function; 8 EGFR Signalling in EMT; E-cadherin in EGFR Signalling; EGFR Signalling Path to EMT; ECM and Cell Membrane Components in EGFR Signalling; EGFR and TGF-[beta] Signalling Pathways Interact in EMT. Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. Cancer Genetic aspects. Cancer Molecular aspects. Cancer Treatment. Neoplasms genetics. Neoplasms therapy. Genetic Therapy methods. Electronic books. Available for University of the Philippines Baguio with URL: http://www.sciencedirect.com/science/book/9780124165700. Click here to request https://forms.gle/KZjBv7aRtY6jiL5E9 (viewed 09 June 2021) FO Monograph UPBAG UPBAG-MAIN BC-ebook Electronic Resource