00000cmm a22000003a 4500 UP-1685594773862075460 Buklod 20170314150446.0 g||| | || || ta 170314s2013 xx u eng d 9780124160040 (ebook) (iLib)UPBAG-00023564291 DML BAG rda eng ML-ebook Immune biology of allogeneic hematopoietic stem cell transplantation [electronic resource] models in discovery and translation edited by Gâerard Sociâe and Bruce R. Blazar. Amsterdam Elsevier/AP [2013] 1 online resource (xviii, 518 pages) illustration text txt rdacontent computer rdamedia online resource cr rdacarrier Includes bibliographical references and index. Front Cover; Immune Biology of Allogeneic HematopoieticStem Cell Transplantation: Models in Discovery and Translation; Copyright; Contents; Contributors; Foreword; Abbreviations; Chapter 1 -- Overview of the immune biology of allogeneic hematopoietic stem cell transplantation; Introduction; Immune rejection; Immune deficiency; GVHD pathophysiology; The graft-versus-leukemia effect; References; Chapter 2 -- The HLA system in hematopoietic stem cell transplantation; Introduction; Classical HLA; The role of classical HLA in unrelated donor hematopoietic cell transplantation. Chapter 5 -- Immune rejection: the immune biology of allogeneic hematopoietic stem cell transplantation (from mice to humans)Introduction; Hematopoietic space and microenvironment; Effector mechanisms of graft rejection; Impact of pretransplant conditioning on effector mechanisms of rejection; Impact of MHC-matching on risk of rejection -- from mice to humans; Impact of donor cells on risk of rejection -- from mice to humans; Impact of post-transplant immunosuppression on risk of rejection; Future directions; References; Chapter 6 -- Strategies to improve post-transplant immunity; Introduction. Immunotherapeutic targeting of hematopoietic mHagsToward a broad and more effective application of mHag therapy; Controlling naturally existing and mHag-specific CD8+ regulatory T cells; Concluding remarks; References; Chapter 4 -- In vivo imaging of graft-versus-host disease and graft-versus-leukemia; Introduction; Bioluminescence imaging; In vivo fluorescence imaging; Nuclear imaging (PET/SPECT); Magnetic resonance imaging; Multimodal imaging of GVHD and anti-tumor responses; Advances in imaging technology; Conclusion; References. Post-transplant immune deficiencyGVHD of the thymus; Interleukin-7; Keratinocyte growth factor; Sex steroid ablation; Growth hormone; T-cell precursors; Interleukin-22; Flt3L; Other cytokines and growth factors; Conclusions; References; Chapter 7 -- Tumor-associated antigens; Introduction; Biology of tumor-associated antigens; Aberrantly expressed self-antigens; Tumor-specific antigens; Mutated self-antigens; Cellular approaches to targeting TAA; Unanswered questions; Conclusion; References; Chapter 8 -- Impact of the conditioning regimen. The clinical significance of non-classical HLA genes: HLA-E, (HLA-F), HLA-G and MIC genesConclusions; Acknowledgments; References; Chapter 3 -- The impact of minor histocompatibility antigens in allogeneic stem cell transplantation; From immunobiology to the impact of mHags in GVHD and GVT; Murine mHags, challenges for the human system; Immunobiology and biochemical identity of mHags; Mechanisms of generation of mHags; The impact of individual mHags on GVHD and GVT; To match or to mismatch: paradigm shifts in the mHag field; Hematopoietic mHags: ideal targets for separating GVT from GVHD. This book provides clinical and scientific researchers with a deep understanding of the current research and the implications for translational practice. By providing an overview of immune biology of HSCT, an explanation of immune rejection and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. Blood Diseases. Graft versus host disease. Hematopoietic stem cells Transplantation. Immunology. Hematopoietic Stem Cell Transplantation. Graft vs Host Disease immunology. Transplantation Immunology. Transplantation, Homologous immunology. Electronic books. Blazar, Bruce R. editor. Sociâe, Gâerard. editor. Available for University of the Philippines Baguio with URL:http://www.sciencedirect.com/science/book/9780124160040. Click here to request https://forms.gle/KZjBv7aRtY6jiL5E9 (viewed 09 June 2021) FO Monograph UPBAG UPBAG-MAIN ML-ebook Electronic Resource