The effect of red wine extract, reserveratrol, on the degree and rate of orthodontic tooth movement in guinea pigs - Urriquia, Isidro ALex C.
The present study examined the effect of red wine extract, resveratrol, on the degree and rate of experimental orthodontic tooth movement in guinea pigs. Guinea pigs were randomly assigned into one of two test groups (low dose resveratrol and high dose resveratrol) and a control group. Each group received study treatments for 28 days, l O days prior to placement of orthodontic appliance and 18 days thereafter. Direct linear measurements of tooth separation were documented at days 12 to 28. Comparing the mean degree of tooth separation showed a significant difference between the resveratrol groups and the control group. A highly significant difference was found between the mean rates of tooth movement among the three treatment groups on day 7 (P=0.000) and day 8 (P=0.018) of appliance placement with the two resveratrol groups being similar and both being different from the control group. It was also shown that there was a highly significant difference between the mean degree of tooth separation between the resveratrol groups and the control group from day 9 of appliance placement (P=0.049) to day 18 of appliance placement (P=0.000), with the low dose and high dose resveratrol group having similar degree of tooth separation. Results of this study suggest that resveratrol, both at low and high doses, has an inhibitory effect on the degree and rate of orthodontic tooth movement in guinea pigs.
Keywords: Orthodontic; Resveratrol; Orthodontic appliances