Investigation of the applicability of cellular thermal shift assay (CETSA) for monitoring HMG-COA reductase levels in HCT-116

Poor success rates of drug development process may be due to lack of determination of target engagement on a more suitable assay system. CETSA is a novel technique which monitors target engagement in unmodified proteins through the measurement of thermal shift of target protein with ligand when expo...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Almario, Trystam Eymar R.​ (Συγγραφέας), Velasquez, Dethalee Gabrielle R.​ (Συγγραφέας)
Άλλοι συγγραφείς:	Rodriguez, Czarina Dominique R.​ (thesis adviser.), Bascos, Neil Andrew D.​ (thesis co-adviser.), Yu, Gracia Fe B.​ (thesis co-adviser.)
Μορφή:	Thesis
Γλώσσα:	English
Θέματα:	Hydroxymethylglutaryl coenzyme A reductases. Cellular Thermal Shift Assay (CETSA).