00000ctm a22000003i 4500 UP-1685523046126336292 Buklod 20190813104845.0 m |o d | ta 190813s2019 xx d r |||| u| (iLib)UPMNL-00016535180 ​​​​UPPharm rda eng LG 993.5 2019 P5 A73 Arcenas, Ma. Giselle D.​ author Optimization of clopidogrel nanoparticles formulation by Jassim & Hussein, 2014 using polyvinyl alcohol (PVA) & polyvinylpyrrolidone (PVP) K30 Ma. Giselle D. Arcenas, Mary Lord Sheehan B. Olinares, Cleo P. Valiente ; adviser, Jean Flor C. Casauay ; co-adviser, Clinton B. Gomez. Manila College of Pharmacy, University of the Philippines 2019. 49 leaves text rdacontent unmediated rdamedia volume rdacarrier ​Thesis (Bachelor of Science in Industrial Pharmacy)--University of the Philippines, June 2019. Yes - available to the general public. The study aims to optimize clopidogrel nanoparticles formulated by Jassim and Hussein (2014) using a combination of PVA and PVP K30 polymers as stabilizers with modifications on the size of the needle gauge and stirring speed. Clopidogrel nanoparticles were produced via antisolvent-precipitation method at drug:stabilizer ratio of 1:1, 1:2 and 1:4 and at stabilizer:stabilizer ratio of 2:1, 1:1 and 1:2. The formulated clopidogrel nanoparticles were characterized for surface morphology, particle size distribution, zeta potential, drug encapsulation efficiency, in vitro dissolution and drug-stabilizer compatibility. All resulting nanosuspensions (F1 to F9) appeared as clear solutions with water-like consistency and with absence of agglomerations. SEM of clopidogrel nanoparticles confirmed relatively spherical in shape and surface which varies from rough to smooth. F8 showed a monodisperse distribution in dynamic light scattering with an average size and polydispersity index of 816.3 nm and 0.505, respectively. F5 has the most ideal zeta potential (-33.180 mV), F4 has the highest drug entrapment efficiency (99.5843%), and F9 has the highest in-vitro drug release (13.0381%). FTIR study also revealed that there is no chemical interaction between clopidogrel and the stabilizers. Clopidogrel nanoparticles were successfully formulated using Jassim and Hussein?s (2014) anti-solvent precipitation method with modifications on needle gauge size (26G) and stirring speed (1000 rpm). However, further testing should be done, particularly on the particle size distribution, to determine the optimum clopidogrel nanoparticles formulation. Clopidogrel. Nanoparticles. Polyvinyl alcohol. Povidone. Olinares, Mary Lord Sheehan B.​ author. Valiente, Cleo P.​ author. Casauay, Jean Flor C.​ thesis adviser. Gomez, Clinton B.​ thesis co-adviser. FI UP UPMNL PHARM LG 993.5 2019 P5 A73 Thesis