00000cam a22000004a 4500 UP-1685523046126335588 Buklod 20171109164410.0 m |o d | ta 171109s2011 xx d r |||| u| 9780521886451 (hardback) (iLib)UPMNL-00015613438 DNLM UPM PHARM rda eng RM 301.25 T73 2011 Translational medicine and drug discovery edited by Bruce H. Littman, Rajesh Krishna. New York Cambridge University Press c2011. xx, 361 pages illustrations 26 cm. text rdacontent unmediated rdamedia volume rdacarrier Includes bibliographical references and index. Section I. Translational medicine: history, principles and application in drug development: 1. Translational medicine:definition, history, and strategies/ Bruce H. Littman -- 2. Translational medicine and its impact on diabetes drug development / Roberto A. Calle and Ann E. Taylor -- 3. Challenges in atherosclerosis / John S. Millar -- 4. Obesity: new mechanisms and translational paradigms / Gregory Gaich and David E. Moller -- 5. Bone disorders: translational medicine case studies / S. Aubrey Stoch -- 6. Case studies in neuroscience: unique challenges and examples / Gerard J. Marek -- 7. Translational medicine in oncology / Dominic G. Spinella; Section II. Biomarkers and public-private partnerships: 8. Biomarker validation and application in early drug development: idea to proof of concept/ Pfizer Global Research and Development, 2004 -- 9. Image biomarkers in drug development: case studies / Johannes T. Tauscher and Adam J. Schwarz -- 10. European new safe and innovative medicine initiatives: history and progress (through December 2009) / Ole J. Bjerrum and Hans H. Linden -- 11. Critical path institute and the predictive safety testing consortium / Elizabeth Gribble Walker -- 12. The biomarker consortium: facilitating the development and qualification of novel biomarkers through a precompetitive public-private partnership / David Wholley and David B. Lee; Section III. Future Directions: 13. Improving the quality and productivity of pharmacometric modeling and simulation activities: the foundation for model-based drug development / Thaddeus H. Grasela, Jill Fiedler-Kelly, and Robert Slusser -- 14. Embracing change: a pharmaceutical industry guide to the 21st century / Mervyn Turner. "Focuses on the new discipline of translational medicine as it pertains to drug development within the pharmaceutical and biotechnology industry"--Provided by publisher. Drug development. Molecular pharmacology. Drug Discovery. Translational Medical Research methods. Littman, Bruce H. 1944- editor. Krishna, Rajesh editor. FO UPMNL PHARM RM 301.25 T73 2011 Book