00000ctm a22000003a 4500 UP-1685523046126318448 Buklod 20170822120338.0 m |o d | ta 170822s2017 xx d r |||| u| (iLib)UPMNL-00015498165 UPM PHARM rda eng LG 993.5 2017 P5 C37 Casimpan, Guinevere A.​ author. Alpha-glucosidase inhibitory activity of a tablet formulated from Chrysophyllum cainito L. (Fam. Sapotaceae) leaves extract Guinevere A. Casimpan, Kimberly P. Castro, Khristelle C. Eñano, ; adviser, Ethel Andrea C. Ladignon. ​​​​​​​​​​Manila: Department of Industrial Pharmacy, College of Pharmacy, University of the Philippines Manila 2017. ​​ ix, 69 leaves color illustrations 28 cm. ​​​​text rdacontent unmediated rdamedia volume rdacarrier Available to the general public. ​​​​​​Thesis (Bachelor of Science in Industrial Pharmacy)--University of the Philippines Manila, May 2017. ​ Diabetes remains a global threat, with the Philippines as one of its emerging hotspots. Alpha-glucosidase inhibitors are recommended as first?line therapy and Chrysophyllum cainito leaves have a great potential in having this activity. However,it has no available dosage forms yet. Thus, this study aims to evaluate the alpha-glucosidase inhibitory activity of a tablet formulated from C. cainito leaves extract. The milled sample was collected from a farm in Negros Occidental,Philippines. Cold maceration process using distilled water and subsequent evaporation to dryness were done to obtain the crude extract. The crude extract was re-dissolved and fumed silica was added. The mixture was lyophilized and the resulting powder acted as the active ingredient. This was formulated into a tablet via direct compression method. The drug-excipient compatibility study results suggest that acidic excipients should not be used in the formulation. Both the crude extract and the tablet had undergone alpha?glucosidase inhibitory bioassay. It was found that there is only a minor difference between the inhibitory activity of the crude extract (1C50= 116.78 ug/mL)and that of the tablet (1C50= 121.1l ug/mL). Additional formulation and bioassay trials are recommended to conduct statistical analysis. Sapotaceae. Plant extracts. Glucosidase inhibitors. Castro, Kimberly P.​ author. Eñano, Khristelle C.​ author. Ladignon, Ethel Andrea C. thesis adviser. FI UP UPMNL PHARM LG 993.5 2017 P5 C37 Thesis