00000cam a22000008i 4500 UP-1685523046126236918 Buklod 20130128170932.0 m |o d | ta 130128s2012 xx d r |||| u| 9780470261231 (iLib)UPMNL-00012617566 Ph-8562 Linar Php7147.00 UPPharm eng RM 301.25 S97 2012 Systems biology in drug discovery and development edited by Daniel L. Young, Seth Michelson. Hoboken, NJ Wiley c2012. xvii, 370 pages illustrations 25 cm. text rdacontent unmediated rdamedia volume rdacarrier Wiley series on Technologies for the Pharmaceutical Industry Includes bibliographical references. Introduction to systems biology in drug discovery and development -- Methods for in silico biology : model construction and analysis -- Methods in in silico biology : modeling feedback dynamics in pathways -- Simulation of population variability in pharmacokinetics -- Applications of systems biology approaches to target identification and validation in drug discovery -- Lead identification and optimization -- The role of core biological motifs in dose-response modeling : an example with switch-like circuits -- Mechanism based pharmacokinetic-pharmacodynamic modeling during discovery and early development -- Developing oncology drugs using virtual patients of vascular tumor diseases -- Systems modeling applied to candidate biomarker identification -- Simulating clinical trials -- Pathway analysis in drug discovery -- Functional mapping for predicting drug response and enabling personalized medicine -- Future outlook of systems biology. Drug development. Systems biology. Drug Discovery methods. Models, Biological. Pharmacokinetics. Pharmacological Processes. Systems Biology methods. Young, Daniel L. editor of compilation. Michelson, Seth. editor of compilation. FO UPMNL PHARM RM 301.25 S97 2012 Book