Systems biology in drug discovery and development - Young, Daniel L.; Michelson, Seth. (Hoboken, NJ Wiley, 2012)
Introduction to systems biology in drug discovery and development -- Methods for in silico biology : model construction and analysis -- Methods in in silico biology : modeling feedback dynamics in pathways -- Simulation of population variability in pharmacokinetics -- Applications of systems biology approaches to target identification and validation in drug discovery -- Lead identification and optimization -- The role of core biological motifs in dose-response modeling : an example with switch-like circuits -- Mechanism based pharmacokinetic-pharmacodynamic modeling during discovery and early development -- Developing oncology drugs using virtual patients of vascular tumor diseases -- Systems modeling applied to candidate biomarker identification -- Simulating clinical trials -- Pathway analysis in drug discovery -- Functional mapping for predicting drug response and enabling personalized medicine -- Future outlook of systems biology.
Includes bibliographical references.
Keywords: Drug development; Systems biology; Drug Discovery -- methods; Models, Biological; Pharmacokinetics; Pharmacological Processes; Systems Biology -- methods