00000cam a22000004a 4500 UP-1685523046126236767 Buklod 20121206143007.0 m |o d | ta 121206s2012 xx d r |||| u| 9781259011115 (iLib)UPMNL-00012502491 Ph-8536 Megatexts Php3400.00 UPPharm eng RM 301.4 S52 2012 Shargel, Leon 1941- Applied biopharmaceutics & pharmacokinetics Leon Shargel, Susanna Wu-Pong, Andrew B.C. Yu. Applied biopharmaceutics and pharmacokinetics. 6th edition. New York McGraw-Hill Medical c2012. xviii, 811 pages illustrations 25 cm. text rdacontent unmediated rdamedia volume rdacarrier Includes bibliographical references and index. Introduction to biopharmaceutics and pharmacokinetics -- Mathematical fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dose adjustment in renal and hepatic disease -- Physiologic pharmacokinetic models, mean residence time, and statistical moment theory. Also available online. Biopharmaceutics. Pharmacokinetics. Biopharmaceutics. Models, Chemical. Pharmacokinetics. Yu, Andrew B. C. 1945-. Wu-Pong, Susanna. UPMNL PHARM RM 301.4 S52 2012 Book