00000ctm a22000004a 4500 UP-1685523046125428381 Buklod 20230503092606.0 a r |||| u| ta 071031s xx d r |||| u| (iLib)UPMNL-00000055732 UPMain eng LG 995 2002 O25 G35 Galban, Angelita B. The local neurotoxic effects of methyl methacrylate among exposed dental technicians in Manila Angelita B. Galban. 77 leaves. Thesis (Master of Occupational Health)--University of the Philippine Manila. A total of 48 technicians working with methyl methacrylate (exposed group) were compared with 26 technicians not working with the monomer (unexposed group) in a cross-sectional study. This study aimed to characterize methyl methacrylate related peripheral neuropathy, determine if there is an association between the disease and work exposure, and measure and compare urine levels of the monomer among the exposed and unexposed technicians. For all subjects the following were done: nerve stimulation tests on specific sensory and motor nerves, measurement of hand and pinch grips, neurological examination for sensory perception changes, survey of clinical signs and symptoms being experienced and measurement of urine levels of the monomer derivative, trichloroethyl methacrylate ester. There were 31 out of 48 (64%) exposed subjects who had abnormal nerve stimulation test results as compared to only 3 out of 26 (11%) among the unexposed. As regards grip measurements, 5 out of 48 (10%) exposed had below normal grips with abnormal nerve stimulation tests against 1 out of 26 (4%) among the unexposed. It was only among the exposed technicians where sensory changes in pain, vibration and temperature perceptions were observed (6 out of 48 or 12%) which ranged from mild to severe deficits. Clinical signs and symptoms reported by both groups of subjects were numbness, coldness, pain and pallor. There were 29 out of 48% (60%) of the exposed and 14 out of 26 (54%) of the unexposed with these manifestations. Between the two groups, urine levels of the monomer derivative tricholoroethyl methacrylate ester were detected more frequently among the exposed (26 out of 48 or 54%) than the unexposed (1 out of 26 or 4%). Findings of this study further revealed that subclinical cases of peripheral neuropathy associated with methyl methacrylate exposure can occur. Chi-square tests showed that there were no significant associations found between signs and symptoms, grip measurements, sensory perceptions and the resulting abnormal nerve stimulation tests. Logistic regression analysis showed that peripheral neuropathy was significantly associated with work exposure to the monomer (p=0.0164) which places exposed technicians at higher risk of developing the disease that the unexposed (odds ratio 168). Dental technicians Manila (Philippines). Methyl methacrylate Toxicology. FI UPMNL CPH LG 995 2002 O25 G35 UPMNL DENT LG 995 2002 O25 G35 UPMNL UPMNL-MAIN LG 995 2002 O25 G35 Thesis