00000ctm a22000007a 4500 UP-1685523046125413727 Buklod 20230503092606.0 m |o d | ta 071031s xx d r |||| u| (iLib)UPMNL-00000055075 ​​​​UPM PHARM eng LG 995 1965 P41 S25 Santos, Patrocinio (Sevilla) 1909- Antibiotic constituents of a Philippine Lichen Usnea Sp. Patrocinio Sevilla Santos. 92 leaves Available to the general public. Thesis (Master of Science in Pharmaceutical Chemistry)--University of the Philippines, 1965. A Philippine lichen "lumot niyog" which is claimed to be used medicinally has been studied and identified as Usnea montagnei Motyka. The lichen thallus possesses antibiotic activity and inhibits the gram-positive bacteria Micrococcus pyogenes aureus 209 P, M. pyogenes aureus (penicillin resistant local strain), Bacillus subtilis FDA 219 and the Mycobacterium M. tuberculosis 607. The gram-negative test bacteria and test fungi are not inhibited. From the lichen thallus, d-usnic acid (1.17%) and salazinic acid (4.03%) were obtained. Results of the molecular weight determination, elementary micro-analysis, mixed melting point determinations, paper chromatographic analysis, preparation of derivatives, substantiated with ultraviolet analyses proved their identities. The minimum inhibitory concentration of usnic acid for B. subtilis FDA 219, is 1 ug per ml, for M. pyogenes aureus 209 P and M. pyogenes aureus (penicillin resistant local strain) 2 ug per ml and for M. tuberculosis 607, 3 ug per ml. The minimum inhibitory concentration of salazinic acid for M. pyogenes aureus (penicillin resistant local strain) is 1000 ug per ml. Lichens. FI UP UPMNL PHARM LG 995 1965 P41 S25 Thesis