00000ctm a22000007a 4500 UP-1685523046125400502 Buklod 20230503092606.0 m |o d | ta 071031s xx d r |||| u| (iLib)UPMNL-00000054162 UPM PHARM ​​eng LG 993.5 1996 P5 G68 Gotera, Johanna R. A comparative study on the dissolution and disintegration properties of three ascorbic acid tablet formulations Johanna R. Gotera, Sheryll Anne M. Romero. Manila Department of Industrial Pharmacy, College of Pharmacy, University of the Philippines 1996. 42 leaves ​Thesis (Bachelor of Science in Industrial Pharmacy)--University of the Philippines, October 1996. Yes - available to the general public. A comparative dissolution and disintegration study was conducted on two generic (Rhea and Unilab) and one brand name (Cetrin) ascorbic acid tablet formulations in two dissolution media: distilled water and simulated gastric fluid. The disintegration was carried out as directed in the USP monograph. On the other hand, no dissolution procedure is specified for ascorbic acid tablet so the general directions in the USP for dissolution of non-coated, non-chewable tablets was employed. The USP Apparatus 2 (Paddle Method) at 50 rpm was used. Samples were withdrawn every 15 minutes for the dissolution in distilled water and every 5 minutes for the dissolution in acid medium. The samples were analysed using uv spectroscopy. The study illustrated that the dissolution study on ascorbic acid tablets employing the above-mentioned method cannot be expected to yield a comparative and meaningful results. No sound conclusions may be drawn from the dissolution profile thus obtained regarding the relative bioavailability of the three ascorbic acid formulations due to the difficulty in handling of ascorbic acid which is sensitive to light and its environment, among other parameters. The study has also shown that the disintegration of an ascorbic acid tablet does not necessarily ensure the bioavailability of ascorbic acid. Vitamin C. Romero, Sheryll Anne M. FI UP UPMNL PHARM LG 993.5 1996 P5 G68 Thesis