00000nmm a2200000 i 4500 UP-1685474870047060134 Buklod 20230510150359.0 m o u cr ||||||||||| 230404s2014 ne u eng d 9780123979186 (OCoLC)894270384 OCLCO DSCI rda eng QP 606 P76 P76 2014eb Protein kinase inhibitors in research and medicine edited by Kevan M. Shokat. Amsterdam Elsevier/Academic Press [2014] 1 online resource (xii, 241, 42 unnumbered pages of plates) illustrations (some color) text rdacontent computer rdamedia online resource rdacarrier Methods in enzymology volume 548 Includes bibliographical references and indexes. Catalytic mechanisms and regulation of protein kinases / Zhihong Wang and Philip A. Cole -- A structural atlas of kinases inhibited by clinically approved drugs / Qi Wang, Julie A. Zorn, and John Kuriyan -- Fragment-based approaches to the discovery of kinase inhibitors / Paul N. Mortenson, Valerio Berdini, and Marc O'Reilly -- Targeting protein kinases with selective and semi-promiscuous covalent inhibitors / Rand M. Miller and Jack Taunton -- The resistance tetrad: amino acid hotspots for kinome-wide exploitation of drug-resistant protein kinase alleles / Fiona P. Bailey, Veselin I. Andreev, and Patrick A. Eyers -- FLiK: a direct binding assay for the identification and kinetic characterization of stabilizers of inactive kinase conformations / Jeffrey R. Simar and Daniel Rauh -- Discovery of allosteric BCR-ABL inhibitors from phenotypic screen to clinical candidate / Nathanael S. Gray and Doriano Fabbro -- The logic and design of analog-sensitive kinases and their small molecule inhibitors / Michael S. Lopez, Joseph I. Kliegman, and Kevan M. Shokat IP-based subscription, on campus only. Access via Electronic Resources of the UPD University Library Website. Protein kinases Inhibitors. Electronic books. Shokat, Kevan editor. Methods in enzymology volume 548. Available for University of the Philippines System via Science Direct. Also available remotely for University of the Philippines System via Science Direct through. Click here to access thru Open Athens: https://www.sciencedirect.com/bookseries/methods-in-enzymology/vol/548/suppl/C (viewed 04 April 2023) FO UPD DSCI Electronic Resource