00000cab a22000004a 4500 IPP-00000277151 IPP 20190208160149.0 190208s2011 xx d | ||r |||||eng|| eng Guillermo, Leny I. Phytochemical screening and evaluation of and indigenous plant species, Papait (Molunggo oppositifolia) as a potential anti-diabetic plant 2011 The development and exploration of the remaining Philippine indigenous lants as a botanical resource remain a researcheable area not only in medicine but also in biodiversity conservation. Papait (Mollungo oppositifolia) is very common weed indigenous to the Philippines. The whole plant is eaten as a vegetable by local folks and is claimed to have anti-diabetic effects and is reported lately as exceptionally rich in iron and calcium. The study aimed to determine the phytochemicals present in Papait leaf extract and evaluate its potentials to lower blood glucose level of white mice. The study was laid in Completely Randomized Design (CRD) in 5 treatments: T1 (0.0025 ml PLE/g wt of mice), T2 (0.005 ml PLE/g wt of mice), T3 (0.0075 ml PLE/g wt), T4 (0.01 ml PLE/g wt) and T5 (control-insulin). The extract was orally fed to hyperglycaemic mice. Phytochemical screening of the leaf extract showed this to be very rich in phytochemicals including alkaloids, saponins, steroids, fixed oils and proteins. All the treatments exhibited comparable degrees of potency in lowering blood glucose levels in both sexes of white mice. Percentage (%) reduction of BGL as affected by Papait leaf extract in all the mice was comparable to percentage reduction caused by insulin. The results remarkably demonstrated comparable effect of the plant with the anti-diabetic drug insulin. It is concluded that Papait Leaf Extract can be used as a component material for the preparation of anti-diabetic drugs. It likewise confirms claims of folkloric medicine that the Papit plant can lower blood sugar level hence, it can be a very good complement or substitute for the expensive commercially available anti-diabetic drugs. Indigenous crops Weeds Medicinal plants Phytochemicals Estira, Flordeliz R. Transactions of the National Academy of Science and Technology Vol. 33, no. 1 (Jul. 2011), 82 UPD DMLP Article FI